Year: 2014

The changing abuse ecology: implications for evaluating the abuse pattern of extended-release oxymorphone and abuse-deterrent opioid formulations

Theresa A. Cassidy, Jared Beaumont, Veronica Urdaneta, Simon H. Budman, Stephen F. Butler Presented at PAINWeek 2014 See our poster for “The changing abuse ecology: implications for evaluating the abuse pattern of extended-release oxymorphone and abuse-deterrent opioid formulations” here Abstract Purpose FDA Guidelines released in January 2013 on evaluating abuse-deterrent formulations (ADFs) recommend direct comparison… Read more »

Two Cases of Intranasal Naloxone Self-Administration in Opioid Overdose

Authors: Green, T. C.; Bowman, S. E.; Ray, M.; McKenzie, M.; Rich, J. D. Journal Substance Abuse, Volume 35, 2014 – Issue 2 ABSTRACT Background: Overdose is a leading cause of death for former prisoners, exacting its greatest toll during the first 2 weeks post release. Protective effects have been observed with training individuals at high risk… Read more »

Comparing abuse of extended-release versus immediate-release opioid analgesics adjusted for number of prescriptions and morphine-equivalent dose

Stephen F. Butler, PhD, Theresa A. Cassidy, MPH, Taryn Dailey,  BA1, & Paul M. Coplan, ScD2, Presented at CPDD 2014 See our poster for “Comparing abuse of extended-release versus immediate-release opioid analgesics adjusted for number of prescriptions and morphine-equivalent dose” here Abstract Aims: It has been suggested that abuse risk of extended-release (ER) opioids is… Read more »

Evaluation of an ADF product’s route of administration profile

Theresa A. Cassidy, MPH, Simon H. Budman, PhD, Stephen F. Butler, PhD Presented at CPDD 2014 See our poster for “Evaluation of an ADF product’s route of administration profile” here Abstract Aims: Assessing the impact on abuse patterns of the introduction of abuse deterrent opioid formulations (ADFs) has focused, in part, on comparisons of the… Read more »

From Documenting Death to Comprehensive Care: Applying Lessons from the HIV/AIDS Epidemic to Addiction

Authors: Wakeman, S. E.; Green, T. C.; Rich, T. Am J Med. 2014 Jun; 127(6): 465–466. Published online 2014 Jan 9. doi:  10.1016/j.amjmed.2013.12.018 Abstract In recent years, we have seen a rising tide of deaths documented in Centers for Disease Control and Prevention reports that bears a chilling familiarity to the early years of the human immunodeficiency virus… Read more »

Monitoring of Internet Forums to Evaluate Reactions to the Introduction of Reformulated OxyContin to Deter Abuse

Authors: Emily C McNaughton, MPH,1 Paul M Coplan, ScD,2,3 Ryan A Black, PhD,4 Sarah E Weber, BS,1 Howard D Chilcoat, ScD,2,5 and Stephen F Butler, PhD1 J Med Internet Res. 2014 May; 16(5): e119. Published online 2014 May 2. doi:  10.2196/jmir.3397 Abstract Background Reformulating opioid analgesics to deter abuse is one approach toward improving their benefit-risk balance. To assess sentiment and attempts to defeat… Read more »

Spanish translation and linguistic validation of the screener and opioid assessment for patients with pain-revised (SOAPP-R).

Based on a recent study, our team has published an article titled, “Spanish translation and linguistic validation of the screener and opioid assessment for patients with pain-revised (SOAPP-R).” To access the full text, click here. Abstract INTRODUCTION: Given the increase in misuse and abuse of prescription opioids, clinicians clearly benefit from a standardized tool to… Read more »

Electronic Opioid Risk Assessment Program for Chronic Pain Patients: Barriers and Benefits of Implementation

Authors: Butler, S. F., Zacharoff, K., Charity, S., Lawler, K. and Jamison, R. N. Pain Practice, 14: E98–E105. doi:10.1111/papr.12141, 2014 Abstract Objectives A preliminary electronic pain assessment program known as Pain Assessment Interview Network, Clinical Advisory System (PainCAS), was implemented in 2 pain centers over the course of 10 months to understand the tool’s impact on opioid… Read more »

Changes in Prevalence of Prescription Opioid Abuse after Introduction of an Abuse-Deterrent Opioid Formulation

Authors: Cassidy, T. A.; DasMahapatra, P.; Black, R. A.; Wieman, M. S.; Butler, S. F. Pain Medicine, 15: 440–451. doi:10.1111/pme.12295, 2014 Abstract Objective The reformulation of oxycodone hydrochloride controlled-release (CR) tablets in August 2010 created a natural experiment at a national scale, providing an opportunity to evaluate patterns of abuse of prescription opioids and other drugs… Read more »

Inflexxion, Inc. Approved for Funding Award

Inflexxion, Inc. Approved for Funding Award by the Patient-Centered Outcomes Research Institute Funding will support Inflexxion’s study of chronic pain patients’ use of innovative technology to improve care coordination and patient engagement January 22, 2014 – Newton, MA – Inflexxion, a leader in health care information technology with world-class subject matter experts and a research staff… Read more »